Milzschwellung, Diazo- und Urochromogenreaktion

How nucleophilic are diazo compounds?

The kinetics of the reactions of benzhydryl cations with eight diazo compounds 1 a-g were investigated photometrically in dichloromethane. The nucleophilicity parameters N and slope parameters s of these diazo compounds were derived from the equation log k (20 degrees C)=s (E+N) and compared with the nucleophilicities of other pi systems (alkenes, arenes, silyl enol ethers, silyl ketene acetals...

Diazo test in typhoid fever.

Multi-drug resistant Salmonella typhi is causing serious concern country-wide. In the present study, a combination of cephloridine and gentamicin showed poor response (43.48%) despite in vitro sensitivity, in contrast to 100% response observed by Koul et al.(2). In vivo resistance to cephalexin and gentamicin despite in vitro sensitivity is known(6). On the other hand, ciprofloxacin was success...

Optimized diazo scaffold for protein esterification.

The O-alkylation of carboxylic acids with diazo compounds provides a means to esterify carboxylic acids in aqueous solution. A Hammett analysis of the reactivity of diazo compounds derived from phenylglycinamide revealed that the (p-methylphenyl)glycinamide scaffold has an especially high reaction rate and ester/alcohol product ratio and esterifies protein carboxyl groups more efficiently than ...

Iv. the Diazo Reaction in Urine

Metal-Diazo Radicals of α-Carbonyl Diazomethanes

Metal-diazo radicals of α-carbonyl diazomethanes are new members of the radical family and are precursors to metal-carbene radicals. Herein, using electron paramagnetic resonance spectroscopy with spin-trapping, we detect diazo radicals of α-carbonyl diazomethanes, induced by [Rh(I)Cl(cod)]2, [Co(II)(por)] and PdCl2, at room temperature. The unique quintet signal of the Rh-diazo radical was obs...